A popular actor in the Gujarati film industry, Dharmesh Vyas started his career as an assistant director with Anokha in 2004, before eventually becoming an actor. Some of his notable credits as an actor include Diwangi Ne Had Kar Di (2010), Gujjubhai the Great (2015), Aata Majhi Hatli (2016) and YD Family (2018), a comedy-drama directed by Yash Shreedatt Vyas. His 2019 release includes Order Order Out Of Order, directed by Dhwani Gautam. His 2020 release includes Golkeri.