Ishita Gangulys first television series was Mrs Sinha Roy, a Bengali daily soap on Sananda TV. She then started in the 2014 drama Shastri Sisters opposite Vijayendra Kumeria, and soon became well-known. In 2015, she had a cameo appearance in Star Plus' Tu Mera Hero and had an episodic role in &TV's horror series Darr Sabko Lagta Hai.In 2016, Ganguly started Kamini Nehra in Colors TV's Ishq Ka Rang Safed alongside Mishal Raheja and Navya in the episode show Yeh Hai Aashiqui. She next took on the roles of Kashibai in Peshwa Bajirao and Rajkumari Amrusha in Prithvi Vallabh - Itihaas Bhi, Rahasya Bhi. Her next roles were in Vikram Betaal Ki Rahasya Gatha, Shrimad Bhagwat Mahapuran and Jag Janani Maa Vaishno Devi - Kahani Mata Rani Ki. She was also seen as Draupadi in RadhaKrishn and as Manasa in Vighnaharta Ganesha.